Butanethioic acid, 3-oxo-, S-(1,1-dimethylethyl) ester → 2-(2-chloro-4-fluorobenzyl)-3-oxothiobutyric acid S-tert-butyl Ester

反応式

Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:4]=1[Cl:10].[C:11]([S:15][C:16](=[O:21])[CH2:17][C:18](=[O:20])[CH3:19])([CH3:14])([CH3:13])[CH3:12]>>[C:11]([S:15][C:16](=[O:21])[CH:17]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:4]=1[Cl:10])[C:18](=[O:20])[CH3:19])([CH3:14])([CH3:12])[CH3:13]

参加物

反応物 2

HCID 140007Butanethioic acid, 3-oxo-, S-(1,1-dimethylethyl) ester

HCID 27250621-(Bromomethyl)-2-chloro-4-fluorobenzene

生成物 1

HCID 866314542-(2-chloro-4-fluorobenzyl)-3-oxothiobutyric acid S-tert-butyl Ester

実験手順

The title compound was prepared by the method of Preparation 34a using 1-bromomethyl-2-chloro-4-fluorobenzene and 3-oxothiobutyric acid S-tert-butyl ester.

出典と根拠

ORDレコード: ord-c1a2e392d5fe41068188dc5557652c21
出典データセット: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07858640B2

反応ノート

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