Water → 2-Chloro-3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-ol

HRID 2266632ノート

反応式

HRID 2266632 の反応式
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][C:7]2[C:8](=O)[NH:9][C:10]3[C:15]([C:16]=2[CH3:17])=[C:14]([OH:18])[CH:13]=[C:12]([CH3:19])[CH:11]=3)=[CH:4][CH:3]=1.O.P(Cl)(Cl)([Cl:26])=O>>[Cl:26][C:8]1[C:7]([CH2:6][C:5]2[CH:21]=[CH:22][C:2]([Cl:1])=[CH:3][CH:4]=2)=[C:16]([CH3:17])[C:15]2[C:14]([OH:18])=[CH:13][C:12]([CH3:19])=[CH:11][C:10]=2[N:9]=1

参加物

4

反応物 3

HCID 962WaterHCID 24813Phosphorus oxychlorideHCID 686078103-(4-chlorobenzyl)-5-hydroxy-4,7-dimethyl-1H-quinolin-2-one

生成物 1

HCID 1363359252-Chloro-3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-ol

実験手順

A solution of 3-(4-chlorobenzyl)-5-hydroxy-4,7-dimethyl-1H-quinolin-2-one (1.8 g) in phosphorus oxychloride (9.0 mL) was heated at 180° C. in a microwave reactor for 15 minutes. The solution was poured onto a mixture of ice and water and the resulting precipitate collected by filtration, washed with water and then dried to afford title compound, 2.3 g.

後処理

  1. filtrationthe resulting precipitate collected by filtration
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-722860ea07a14d929f56a7c3a0d264e3
出典データセット
uspto-grants-2010_12
特許番号
US07858640B2

反応ノート

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