Dimethylformamide → [2-chloro-3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-yloxy]acetic Acid Methyl Ester

HRID 2266633ノート

反応式

HRID 2266633 の反応式
[Cl:1][C:2]1[C:11]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)=[C:10]([CH3:20])[C:9]2[C:8]([OH:21])=[CH:7][C:6]([CH3:22])=[CH:5][C:4]=2[N:3]=1.CN(C)C=O.C(=O)([O-])[O-].[K+].[K+].[CH3:34][O:35][C:36](=[O:39])[CH2:37]Br>O>[CH3:34][O:35][C:36](=[O:39])[CH2:37][O:21][C:8]1[CH:7]=[C:6]([CH3:22])[CH:5]=[C:4]2[C:9]=1[C:10]([CH3:20])=[C:11]([CH2:12][C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1)[C:2]([Cl:1])=[N:3]2

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 1363359252-Chloro-3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-ol

生成物 1

HCID 86631459[2-chloro-3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-yloxy]acetic Acid Methyl Ester

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

A mixture of 2-chloro-3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-ol (1.7 g), N,N-dimethylformamide (25 mL), potassium carbonate (2.1 g) and bromoacetic acid methyl ester (1.1 g) was stirred at 60° C. overnight. The mixture was cooled to room temperature, diluted with water and the resulting precipitate collected by filtration, washed with water and then dried to afford title compound, 0.53 g.

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationthe resulting precipitate collected by filtration
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-d5125f381c3646228b1a33798a36b80f
出典データセット
uspto-grants-2010_12
特許番号
US07858640B2

反応ノート

読み込み中…