4-Isopropoxyaniline → 5-Fluoropyrimidine-2,4-diamine

HRID 226666

反応式

HRID 226666 の反応式
OC1C=C([NH:8][C:9]2[N:14]=[C:13]([NH:15]C3C=CC=C(O)C=3)[C:12]([F:23])=[CH:11][N:10]=2)C=CC=1.ClC1N=C(Cl)C(F)=CN=1.C(OC1C=CC(N)=CC=1)(C)C>>[F:23][C:12]1[C:13]([NH2:15])=[N:14][C:9]([NH2:8])=[N:10][CH:11]=1

参加物

4

反応物 3

HCID 821124-IsopropoxyanilineHCID 2507052,4-Dichloro-5-fluoropyrimidineHCID 9904854R-112

生成物 1

HCID 2556085-Fluoropyrimidine-2,4-diamine

実験手順

In a manner similar to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and 4-isopropoxyaniline were reacted to yield N2,N4-bis(4-isopropoxy)phenyl)-5-fluoro-2,4-pyrimidinediamine. 1H NMR (CDCl3): δ 7.89 (bs, 1H), 7.47 (d, 2H, J=8.7 Hz), 7.38 (d, 2H, J=9.0 Hz), 6.87 (d, 2H, J=9.0 Hz), 6.83 (d, 2H, J=8.7 Hz); LCMS: ret. time: 27.51 min.; purity: 98%; MS (m/e): 397 (MH+).

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-9319223fe2b74edc864ff7740a27dae5
出典データセット
uspto-grants-2009_07
特許番号
US07557210B2

関連ノート

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