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1-(Pyrazin-2-yl)ethanamine → 5-(2-Ethyl-imidazol-1-yl)-4'-methyl-biphenyl-3-carboxylic acid (1-pyrazin-2-yl-ethyl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(Pyrazin-2-yl)ethanamine | HCID 18519006 | — |
| 反応物 | 5-(2-Ethyl-imidazol-1-yl)-4'-methyl-biphenyl-3-carboxylic acid | HCID 57749783 | — |
| 生成物 | 5-(2-Ethyl-imidazol-1-yl)-4'-methyl-biphenyl-3-carboxylic acid (1-pyrazin-2-yl-ethyl)-amide | HCID 57749788 | — |
反応手順
5-(2-Ethyl-imidazol-1-yl)-4′-methyl-biphenyl-3-carboxylic acid was subject to the amide coupling reaction described in step 3 of Example 3, but replacing C-(5-methyl-pyrazin-2-yl)-methylamine with 1-pyrazin-2-yl-ethylamine, to give 5-(2-ethyl-imidazol-1-yl)-4′-methyl-biphenyl-3-carboxylic acid (1-pyrazin-2-yl-ethyl)-amide, MS (M+H)=412.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07858654B2 |
| 出典データセット | uspto-grants-2010_12 |
| ORD ID | ord-96282cea1b474c03bcd09175464ff903 |
| 出典メモ | uspto-grants-2010_12 |