cis-1,2-Cyclooctanediol → Octanedial

262 ml of aqueous NaIO4 was added drop wise to a vigorously stirred suspension of 105 g chromatographic grade silica gel in 500 ml dichloromethane whereby a white suspension was formed. To the suspension a solution of 6.1 g cis-1,2-cyclo-octanediol in 100 ml dichloromethane was added. The reaction mixture was stirred over night at room temperature, after which the mixture was filtered whereby the residue was washed 3 times with 100 ml dichloromethane. Finally the filtrate was dried over NaSO4, after which the solvent was removed under reduced pressure.

1. customwas formed
2. filtrationafter which the mixture was filtered whereby the residue
3. washwas washed 3 times with 100 ml dichloromethane
4. dry with materialFinally the filtrate was dried over NaSO4
5. customafter which the solvent was removed under reduced pressure

ORDレコード

ord-f4038f6e281247ae963f465999de75be

出典データセット

uspto-grants-2010_12

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07858675B2