2',4'-Dihydroxy-3'-propylacetophenone → 5-(4-((4-Acetyl-3-hydroxy-2-propylphenoxy)methyl)phenylthio)nicotinonitrile

HRID 2267060ノート

反応式

HRID 2267060 の反応式
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:11]=[N:12][CH:13]=[C:14]([CH:17]=2)[C:15]#[N:16])=[CH:5][CH:4]=1.[OH:18][C:19]1[C:24]([CH2:25][CH2:26][CH3:27])=[C:23](O)[CH:22]=[CH:21][C:20]=1[C:29](=[O:31])[CH3:30]>>[C:29]([C:20]1[CH:21]=[CH:22][C:23]([O:1][CH2:2][C:3]2[CH:4]=[CH:5][C:6]([S:9][C:10]3[CH:11]=[N:12][CH:13]=[C:14]([CH:17]=3)[C:15]#[N:16])=[CH:7][CH:8]=2)=[C:24]([CH2:25][CH2:26][CH3:27])[C:19]=1[OH:18])(=[O:31])[CH3:30]

参加物

3

反応物 2

HCID 27751982',4'-Dihydroxy-3'-propylacetophenoneHCID 685358685-(4-(Hydroxymethyl)phenylthio)nicotinonitrile

生成物 1

HCID 685329635-(4-((4-Acetyl-3-hydroxy-2-propylphenoxy)methyl)phenylthio)nicotinonitrile

実験手順

Using the method of Preparation 160 using 5-(4-(hydroxymethyl)phenylthio) nicotinonitrile (1.20 g, 4.95 nmol) and 1-(2,4-dihydroxy-3-propylphenyl)ethanone (1.01 g, 5.20 mmol) affords the title compound. MS (APCI-neg) m/z (rel intensity): 417 (M−H, 100%).

出典と根拠

ORDレコード
ord-82a078484a7c49759137f5e73716e09a
出典データセット
uspto-grants-2010_12
特許番号
US07858646B2

反応ノート

読み込み中…