1-(3-Ethyl-2,4-dihydroxyphenyl)ethanone → 5-(4-((4-Acetyl-2-ethyl-3-hydroxyphenoxy)methyl)phenylthio)nicotinonitrile

HRID 2267061ノート

反応式

HRID 2267061 の反応式
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:11]=[N:12][CH:13]=[C:14]([CH:17]=2)[C:15]#[N:16])=[CH:5][CH:4]=1.[CH2:18]([C:20]1[C:21]([OH:30])=[C:22]([C:27](=[O:29])[CH3:28])[CH:23]=[CH:24][C:25]=1O)[CH3:19]>>[C:27]([C:22]1[CH:23]=[CH:24][C:25]([O:1][CH2:2][C:3]2[CH:4]=[CH:5][C:6]([S:9][C:10]3[CH:11]=[N:12][CH:13]=[C:14]([CH:17]=3)[C:15]#[N:16])=[CH:7][CH:8]=2)=[C:20]([CH2:18][CH3:19])[C:21]=1[OH:30])(=[O:29])[CH3:28]

参加物

3

反応物 2

HCID 212870211-(3-Ethyl-2,4-dihydroxyphenyl)ethanoneHCID 685358685-(4-(Hydroxymethyl)phenylthio)nicotinonitrile

生成物 1

HCID 685350865-(4-((4-Acetyl-2-ethyl-3-hydroxyphenoxy)methyl)phenylthio)nicotinonitrile収率 37.5%

実験手順

Using the method of Preparation 160 using 5-(4-(hydroxymethyl)phenylthio) nicotinonitrile (1.20 g, 4.95 mmol) and 1-(3-ethyl-2,4-dihydroxyphenyl)ethanone (937 mg, 5.20 mmol) affords the title compound (750 mg, 37%): 1H NMR (CDCl3) δ 1.15 (t, J=7.64 Hz, 3H), 2.57 (s, 3H), 2.76 (q, J=7.6 Hz, 2H), 5.22 (s, 2H), 6.47 (d, J=9.0 Hz, 1H), 7.49 (d, J=8.2 Hz, 2H),), 7.52 (d, J=8.2 Hz, 2H), 7.60 (d, J=9.0 Hz, 1H), 7.63 (dd, J=2.0, 2.3 Hz, 1H), 8.64 (t, J=2.0 Hz, 2H), 12.75 (s, 1H).

出典と根拠

ORDレコード
ord-b48e3241e08f45c086186d1b858056bd
出典データセット
uspto-grants-2010_12
特許番号
US07858646B2

反応ノート

読み込み中…