1-(3-Ethyl-2,4-dihydroxyphenyl)ethanone → 5-(3-((4-Acetyl-2-ethyl-3-hydroxyphenoxy)methyl)phenylthio) picolinonitrile
反応式
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([S:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]#[N:17])=[N:14][CH:15]=2)[CH:6]=[CH:7][CH:8]=1.[CH2:18]([C:20]1[C:21]([OH:30])=[C:22]([C:27](=[O:29])[CH3:28])[CH:23]=[CH:24][C:25]=1O)[CH3:19]>>[C:27]([C:22]1[CH:23]=[CH:24][C:25]([O:1][CH2:2][C:3]2[CH:4]=[C:5]([S:9][C:10]3[CH:11]=[CH:12][C:13]([C:16]#[N:17])=[N:14][CH:15]=3)[CH:6]=[CH:7][CH:8]=2)=[C:20]([CH2:18][CH3:19])[C:21]=1[OH:30])(=[O:29])[CH3:28]参加物
3
実験手順
Using the method of Preparation 166 using 5-(3-(hydroxymethyl)phenylthio) picolinonitrile (1.70 g, 7.02 mmol) and 1-(3-ethyl-2,4-dihydroxyphenyl)ethanone (1.26 g, 7.02 mmol) affords the title compound (2.20 g, 78%). MS (APCI-neg) m/z (rel intensity): 403 (M−H, 100%).
出典と根拠
- ORDレコード
- ord-d806052827fd42c9a9e2181d1b30b456
- 出典データセット
- uspto-grants-2010_12