1-(2,4-Dihydroxy-3-methylphenyl)ethan-1-one → 2-(3-((4-Acetyl-3-hydroxy-2-methylphenoxy)methyl)phenylthio) isonicotinonitrile

HRID 2267068ノート

反応式

HRID 2267068 の反応式
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([S:9][C:10]2[CH:11]=[C:12]([CH:15]=[CH:16][N:17]=2)[C:13]#[N:14])[CH:6]=[CH:7][CH:8]=1.[OH:18][C:19]1[C:24]([CH3:25])=[C:23](O)[CH:22]=[CH:21][C:20]=1[C:27](=[O:29])[CH3:28]>>[C:27]([C:20]1[CH:21]=[CH:22][C:23]([O:1][CH2:2][C:3]2[CH:4]=[C:5]([S:9][C:10]3[CH:11]=[C:12]([CH:15]=[CH:16][N:17]=3)[C:13]#[N:14])[CH:6]=[CH:7][CH:8]=2)=[C:24]([CH3:25])[C:19]=1[OH:18])(=[O:29])[CH3:28]

参加物

3

反応物 2

HCID 5921391-(2,4-Dihydroxy-3-methylphenyl)ethan-1-oneHCID 573554602-{[3-(Hydroxymethyl)phenyl]sulfanyl}pyridine-4-carbonitrile

生成物 1

HCID 685377692-(3-((4-Acetyl-3-hydroxy-2-methylphenoxy)methyl)phenylthio) isonicotinonitrile収率 52%

実験手順

Using the method of Preparation 166 using 2-(3-(hydroxymethyl)phenylthio) isonicotinonitrile (1.46 g, 6.02 mmol) and 1-(2,4-dihydroxy-3-methylphenyl)ethanone (1.00 g, 6.02 mmol) affords the title compound (1.22 g, 52%). MS (APCI-neg) m/z (rel intensity): 389 (M−H, 100%).

出典と根拠

ORDレコード
ord-ebc5f64e2797474d8bf03e3017a24606
出典データセット
uspto-grants-2010_12
特許番号
US07858646B2

反応ノート

読み込み中…