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HRID 226727作成日：2026年10月26日

M-Phenylenediamine → N2-(3-aminophenyl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine

https://huagongshe.com/reaction/226727

反応式

関与物質

役割名称HCID仕込み量
反応物M-PhenylenediamineHCID 7935—
反応物2-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamineHCID 22060451—
生成物N2-(3-aminophenyl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamineHCID 22060474—

反応手順

In like manner to the preparation of N4-(3-aminophenyl)-N2-[2-(methoxycarbonyl)-benzofurane-5-yl]-5-fluoro-2,4-pyrimidinediamine, 2-chloro-5-fluoro-N4-(3-hydroxyphenyl)-4-pyrimidineamine and 1,3-diaminobenzene were reacted to give N2-(3-aminophenyl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine. LCMS: ret. time: 11.89 min.; purity: 97.6%; MS (m/e): 312.05 (MH+).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07557210B2
出典データセットuspto-grants-2009_07
ORD IDord-087dea1b716f488c97cee989669d81c5
出典メモuspto-grants-2009_07