化工社化工社 化学情報印刷レポート · 研究参考用
2-Chloro-1,1-dimethoxyethane → 2-(N-Methyl-N-phenylamino)thiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-1,1-dimethoxyethane | HCID 60986 | — |
| 反応物 | 1-Methyl-1-phenylthiourea | HCID 723631 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-(N-Methyl-N-phenylamino)thiazole | HCID 23459375 | — |
反応手順
A solution of 10 g (60 mmol) of N-methyl-N-phenylthiourea in 100 mL of toluene was treated with 7.2 mL (63 mmol) of chloroacetaldehyde dimethylacetal and heated at reflux for 12 h. The solvent was removed in vacuo and the residue purified by flash chromatography eluting with a linear gradient of 30% EtOAc in hexane to 80% EtOAc in hexane to deliver the title compound. MS (M+H)+ 191.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07858785B2 |
| 出典データセット | uspto-grants-2010_12 |
| ORD ID | ord-c367ec944d73486e8c63d7a0c8109701 |
| 出典メモ | uspto-grants-2010_12 |