Chloroacetaldehyde → N-(4-Fluorophenyl)thiazol-2-amine

HRID 2267397ノート

反応式

HRID 2267397 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH2:11])=[S:10])=[CH:4][CH:3]=1.Cl[CH2:13][CH:14]=O.C(OCC)(=O)C>C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]2[S:10][CH:13]=[CH:14][N:11]=2)=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 33ChloroacetaldehydeHCID 8857Ethyl AcetateHCID 6930614-Fluorophenylthiourea

生成物 1

HCID 25093329N-(4-Fluorophenyl)thiazol-2-amine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

1-(4-fluorophenyl)thiourea (2.00 g, 11.7 mmol) and 2-chloroacetaldehyde (3.72 mL, 58.6 mmol) in anhydrous ethanol (5 mL) were added to a microwave vial. The reaction mixture was heated to 80° C. in a microwave reactor for 20 min. On cooling, ethyl acetate (2 mL) was added to the crude product reaction mixture and pure product crystallized out. This filtered off, washed with hexane and air-dried to afford the title compound as a crystalline brown solid, 1.568 g. MS (M+H)+ 195.

後処理

  1. temperatureOn cooling
  2. customcrystallized out
  3. filtrationThis filtered off
  4. washwashed with hexane
  5. customair-dried

出典と根拠

ORDレコード
ord-3dbbb6f50cdb465bb2efdb4163b817a9
出典データセット
uspto-grants-2010_12
特許番号
US07858785B2

反応ノート

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