Triethylamine → HCID 59003314、化合物

反応式

[C:1]1([C:7]2[CH:8]=[C:9]3[C:13](=[C:14]([C:16]([NH2:18])=[O:17])[CH:15]=2)[NH:12][CH:11]=[C:10]3[C:19]2[CH2:20][CH2:21][NH:22][CH2:23][CH:24]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:25][N:26]1[CH:30]=[C:29]([S:31](Cl)(=[O:33])=[O:32])[N:28]=[C:27]1[CH3:35].C(N(CC)CC)C>>[CH3:25][N:26]1[CH:30]=[C:29]([S:31]([N:22]2[CH2:21][CH2:20][CH:19]([C:10]3[C:9]4[C:13](=[C:14]([C:16]([NH2:18])=[O:17])[CH:15]=[C:7]([C:1]5[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=5)[CH:8]=4)[NH:12][CH:11]=3)[CH2:24][CH2:23]2)(=[O:33])=[O:32])[N:28]=[C:27]1[CH3:35]

参加物

反応物 3

HCID 8471Triethylamine

HCID 27362561,2-Dimethylimidazole-4-sulfonyl chloride

HCID 69146343HCID 69146343、化合物

生成物 1

HCID 59003314HCID 59003314、化合物

実験手順

Following the general procedure in example 267, 5-phenyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole-7-carboxamide (32 mg, 0.1 mmol), 1,2-dimethyl-1H-imidazole-4-sulfonyl chloride (22.8 mg, 0.15 mmol) and triethylamine (0.06 mL, 0.3 mmol) were reacted to form the desired product which was purified by Gilson HPLC (CH3CN/Water, 0.1% TFA) (11 mg, 23%).

後処理

customwere reacted

出典と根拠

ORDレコード: ord-f6452847ef4443ceb79f26e909292275
出典データセット: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07858796B2

反応ノート

読み込み中…