Triethylamine → HCID 59003299、化合物

反応式

[C:1]1([C:7]2[CH:8]=[C:9]3[C:13](=[C:14]([C:16]([NH2:18])=[O:17])[CH:15]=2)[NH:12][CH:11]=[C:10]3[C:19]2[CH2:20][CH2:21][NH:22][CH2:23][CH:24]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:25][N:26]1[C:30]([CH3:31])=[C:29]([S:32](Cl)(=[O:34])=[O:33])[C:28]([CH3:36])=[N:27]1.C(N(CC)CC)C>>[C:1]1([C:7]2[CH:8]=[C:9]3[C:13](=[C:14]([C:16]([NH2:18])=[O:17])[CH:15]=2)[NH:12][CH:11]=[C:10]3[CH:19]2[CH2:20][CH2:21][N:22]([S:32]([C:29]3[C:28]([CH3:36])=[N:27][N:26]([CH3:25])[C:30]=3[CH3:31])(=[O:33])=[O:34])[CH2:23][CH2:24]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

反応物 3

HCID 8471Triethylamine

HCID 27373401,3,5-trimethyl-1H-pyrazole-4-sulfonyl chloride

HCID 69146343HCID 69146343、化合物

生成物 1

HCID 59003299HCID 59003299、化合物

実験手順

Following the general procedure in example 267, 5-phenyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole-7-carboxamide (32 mg, 0.1 mmol), 1,3,5-trimethyl-1H-pyrazole-4-sulfonyl chloride (24.4 mg, 0.15 mmol) and triethylamine (0.06 mL, 0.3 mmol) were reacted to form the desired product which was purified by Gilson HPLC (CH3CN/Water, 0.1% TFA) (9 mg, 18%).

後処理

customwere reacted

出典と根拠

ORDレコード: ord-771a19b37c22485dbc39086fcd7f0a1c
出典データセット: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07858796B2

反応ノート

読み込み中…