Ethanol → 4-Cyclopentylmethoxy-1H-indole-2-carboxylic acid

HRID 2267758ノート

反応式

HRID 2267758 の反応式
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[C:12]([O:15][CH2:16][CH:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1)[CH:11]=[CH:10][CH:9]=2)=[O:5])C.[OH-].[K+].CCO>>[CH:17]1([CH2:16][O:15][C:12]2[CH:11]=[CH:10][CH:9]=[C:8]3[C:13]=2[CH:14]=[C:6]([C:4]([OH:5])=[O:3])[NH:7]3)[CH2:18][CH2:19][CH2:20][CH2:21]1

参加物

4

反応物 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 668413514-Cyclopentylmethoxy-1H-indole-2-carboxylic acid ethyl ester

生成物 1

HCID 668411204-Cyclopentylmethoxy-1H-indole-2-carboxylic acid

実験手順

The 4-cyclopentylmethoxy-1H-indole-2-carboxylic acid ethyl ester 87 obtained above is mixed with a 2M-solution of KOH in EtOH (33.8 ml, 67.6 mmol) and stirred for 24 hours. The solvent is then evaporated and the residue is partitioned between water and ether. The water layer is acidified with HCl and extracted twice with EtOAc. The combined organic layers are washed with brine, dried over anhydrous sodium sulfate, filtered and evaporated to give a white powder.

後処理

  1. customThe solvent is then evaporated
  2. customthe residue is partitioned between water and ether
  3. extractionextracted twice with EtOAc
  4. washThe combined organic layers are washed with brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. filtrationfiltered
  7. customevaporated
  8. customto give a white powder

出典と根拠

ORDレコード
ord-281620a0e99b4ce099dfec8cc795a844
出典データセット
uspto-grants-2010_12
特許番号
US07858781B2

反応ノート

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