1-(2-(Azepan-1-yl)ethyl)piperidin-4-amine trihydrochloride → 4-(5-Chloro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide

反応式

Cl.Cl.[C@H]1([CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([NH:20][C:21]([C:23]3[NH:24][C:25]4[C:30]([CH:31]=3)=[C:29]([O:32][CH2:33][C:34]3[C:38]5[CH:39]=[C:40]([Cl:43])[CH:41]=[CH:42][C:37]=5[O:36][CH:35]=3)[CH:28]=[CH:27][CH:26]=4)=[O:22])[CH2:16][CH2:15]2)[C@@H]2N(CCCC2)CCC1.Cl.Cl.Cl.[N:47]1([CH2:54]CN2CCC(N)CC2)[CH2:53][CH2:52][CH2:51][CH2:50][CH2:49][CH2:48]1>>[N:47]1([CH2:54][CH2:13][N:14]2[CH2:15][CH2:16][CH:17]([NH:20][C:21]([C:23]3[NH:24][C:25]4[C:30]([CH:31]=3)=[C:29]([O:32][CH2:33][C:34]3[C:38]5[CH:39]=[C:40]([Cl:43])[CH:41]=[CH:42][C:37]=5[O:36][CH:35]=3)[CH:28]=[CH:27][CH:26]=4)=[O:22])[CH2:18][CH2:19]2)[CH2:53][CH2:52][CH2:51][CH2:50][CH2:49][CH2:48]1

参加物

反応物 2

HCID 668413931-(2-(Azepan-1-yl)ethyl)piperidin-4-amine trihydrochloride

HCID 66841508HCID 66841508、化合物

生成物 1

HCID 114669664-(5-Chloro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide

実験手順

This compound is synthesized from 4-(5-chloro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid (97, see example 42) and amine 5 analogously to the method described in example 1.

出典と根拠

ORDレコード: ord-9d5c6cfcc81e4de78a3a8b15bf77e845
出典データセット: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07858781B2

反応ノート

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