Methanol → Methyl p-aminosalicylate

反応式

[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([OH:11])[CH:3]=1.[CH3:12]O>>[OH:11][C:4]1[CH:3]=[C:2]([CH:10]=[CH:9][C:5]=1[C:6]([O:8][CH3:12])=[O:7])[NH2:1]

参加物

反応物 2

HCID 887Methanol

HCID 46494-Aminosalicylic Acid

生成物 1

HCID 77787Methyl p-aminosalicylate

実験手順

A solution of 4-amino-2-hydroxybenzoic acid (1 g, 6.5 mmol) in MeOH (15 mL) and concentrated sulfonic acid (1 mL) was refluxed overnight. The reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL). The organic layer was separated, dried, evaporated to give 3-hydroxy-4-methoxycarbonylaniline.

後処理

customThe reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL)
customThe organic layer was separated
customdried
customevaporated

出典と根拠

ORDレコード: ord-2e59af37f17b4ef4879d0356c4247e47
出典データセット: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07557210B2

反応ノート

読み込み中…

参加物