化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → N2,N4-bis(4-carboxy-3-methoxyphenyl)-5-fluoro-2,4-pyrimidinediamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | N2,N4-bis(3-carboxyphenyl)-5-fluoro-2,4-pyrimidinediamine | HCID 10126258 | — |
| 反応物 | N2,N4-bis(3-methoxy-4-methoxycarbonylphenyl)-5-fluoro-2,4-pyrimidinediamine | HCID 22060643 | — |
| 生成物 | N2,N4-bis(4-carboxy-3-methoxyphenyl)-5-fluoro-2,4-pyrimidinediamine | HCID 22060868 | 70% |
反応手順
In a manner analogous to the preparation of N2,N4-bis(3-carboxyphenyl)-5-fluoro-2,4-pyrimidinediamine, N2,N4-bis(3-methoxy-4-methoxycarbonylphenyl)-5-fluoro-2,4-pyrimidinediamine (30 mg, 0.06 mmol) and NaOH (200 mg, 5 mmol) gave N2,N4-bis(4-carboxy-3-methoxyphenyl)-5-fluoro-2,4-pyrimidinediamine (18 mg, 64%) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07557210B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-cae13727090044dbb85ddecc96e76f89 |
| 出典メモ | uspto-grants-2009_07 |