Ammonia → 1-(Pyridin-2-yl)piperidin-4-one
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:16][CH2:15][C:10]2(OCC[O:11]2)[CH2:9][CH2:8]1.S(=O)(=O)(O)O.N>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:8][CH2:9][C:10](=[O:11])[CH2:15][CH2:16]1参加物
4
実験手順
A solution of 8-(2-pyridinyl)-1,4-dioxa-8-azaspiro[4.5]decane (23 g, 0.1 mol) (preparation 36) in 10% w/v sulphuric acid was stirred at room temperature for 8 hr. The reaction mixture was cooled in ice and then the solution adjusted to pH>7 with 0.88 ammonia. The solution was extracted with diethyl ether and the solvent removed from the organic extracts under reduced pressure to give the title compound (14.7 g) as an oil.
後処理
- temperatureThe reaction mixture was cooled in ice
- extractionThe solution was extracted with diethyl ether
- customthe solvent removed from the organic extracts under reduced pressure
出典と根拠
- ORDレコード
- ord-334b9e7078ef42b789688bc9d55a5949
- 出典データセット
- uspto-grants-2001_12
- 特許番号
- US06326359B1
反応ノート
読み込み中…