Sodium methanethiolate → 2-(Methylsulfanyl)-N-phenethyl-9-tetrahydro-2H-pyran-2-yl-9H-purin-6-amine

HRID 2268427ノート

反応式

HRID 2268427 の反応式
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][O:12]2)=[C:4]([NH:17][CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:3]=1.[CH3:26][S-:27].[Na+]>>[CH3:26][S:27][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][O:12]2)=[C:4]([NH:17][CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:3]=1

参加物

3

反応物 2

HCID 4378561Sodium methanethiolateHCID 207091842-Chloro-N-phenethyl-9-tetrahydro-2H-pyran-2-yl-9H-purin-6-amine

生成物 1

HCID 207091892-(Methylsulfanyl)-N-phenethyl-9-tetrahydro-2H-pyran-2-yl-9H-purin-6-amine収率 92.2%

実験手順

The title compound was prepared by a similar method to preparation 7 from 2-chloro-N-phenethyl-9-tetrahydro-2H-pyran-2-yl-9H-purin-6-amine (17.5 g, 49 mmol) (preparation 41) and sodium thiomethoxide (7.2 g, 75 mmol). This gave the title compound (16.7 g) as a white solid.

出典と根拠

ORDレコード
ord-56ed36503f044b758edc202cf67bc883
出典データセット
uspto-grants-2001_12
特許番号
US06326359B1

反応ノート

読み込み中…