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Hydrochloric Acid → 8-(2-Hydroxymethyl-4,5,6,7-tetramethoxyindan-2-yl)octanol

HRID 2268448
ノート
印刷プレビュー

反応式

HRID 2268448 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].C([O:9][C:10]([C:12]1([CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][C:36](OCC)=[O:37])[CH2:20][C:19]2[C:14](=[C:15]([O:27][CH3:28])[C:16]([O:25][CH3:26])=[C:17]([O:23][CH3:24])[C:18]=2[O:21][CH3:22])[CH2:13]1)=O)C.Cl>C(OCC)C>[OH:9][CH2:10][C:12]1([CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][OH:37])[CH2:13][C:14]2[C:19](=[C:18]([O:21][CH3:22])[C:17]([O:23][CH3:24])=[C:16]([O:25][CH3:26])[C:15]=2[O:27][CH3:28])[CH2:20]1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 18348627Ethyl 8-(2-ethoxycarbonyl-4,5,6,7-tetramethoxyindan-2-yl)octanoateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 183485878-(2-Hydroxymethyl-4,5,6,7-tetramethoxyindan-2-yl)octanol収率 95.1%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

Lithium aluminium hydride (72.1 mg, 1.90 mmols) was added to a diethyl ether (6.0 ml) solution of ethyl 8-(2-ethoxycarbonyl-4,5,6,7-tetramethoxyindan-2-yl)octanoate (315 mg, 0.634 mmols), with cooling with ice. The reaction mixture was warmed to room temperature, and then stirred for 1 hour. 1N hydrochloric acid was added to the reaction mixture with cooling with ice, which was then extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, and then dried. The solvent was evaporated out, and the resulting crude product was purified by silica gel column chromatography (hexane:ethyl acetate=4:1 to 1:1) to obtain the entitled compound (239 mg) as an oil.

後処理

  1. temperaturewith cooling with ice
  2. temperaturewith cooling with ice, which
  3. extractionwas then extracted with ethyl acetate
  4. washThe organic layer was washed with a saturated aqueous sodium chloride solution
  5. customdried
  6. customThe solvent was evaporated out
  7. customthe resulting crude product was purified by silica gel column chromatography (hexane:ethyl acetate=4:1 to 1:1)

出典と根拠

ORDレコード
ord-5955a4ef64064b4f868fc5aa35f28134
出典データセット
uspto-grants-2001_12
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06326369B1

反応ノート

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