Ammonia → HCID 178450371、化合物

HRID 2269021ノート

反応式

HRID 2269021 の反応式
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:23]C)[N:6]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.N>Cl>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:23])[N:6]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 109363246-Amino-9-benzyl-2-butoxy-8-methoxypurine

生成物 1

HCID 178450371HCID 178450371、化合物収率 68%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

6-Amino-9-benzyl-2-butoxy-8-methoxypurine (20 mg, 0.061 mmol) in concentrated hydrochloric acid (5 ml) was stirred for 3 hours at room temperature. The reaction mixture was made basic with 28% aqueous ammonia. The resulting crystals were filtered, washed with water, and the crude product was purified by silica gel chromatography (3% methanol/chloroform) to give the subject compound (13 mg, yield 68%).

後処理

  1. filtrationThe resulting crystals were filtered
  2. washwashed with water
  3. customthe crude product was purified by silica gel chromatography (3% methanol/chloroform)

出典と根拠

ORDレコード
ord-ee2430c7a49b4b0895fb247b963887dc
出典データセット
uspto-grants-2001_12
特許番号
US06329381B1

反応ノート

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