Ammonia → HCID 178447010、化合物

HRID 2269022ノート

反応式

HRID 2269022 の反応式
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:24]C)[N:6]2[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.N>Cl>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:24])[N:6]2[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 110242996-Amino-9-benzyl-8-methoxy-2-pentoxypurine

生成物 1

HCID 178447010HCID 178447010、化合物収率 86.2%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

6-Amino-9-benzyl-8-methoxy-2-pentoxypurine (40 mg, 0.117 mmol) in concentrated hydrochloric acid (20 ml) was stirred for 12 hours at room temperature. The reaction mixture was made basic with 28% aqueous ammonia. The resulting crystals were filtered and washed with water to give the subject compound (33 mg, yield 86%).

後処理

  1. filtrationThe resulting crystals were filtered
  2. washwashed with water

出典と根拠

ORDレコード
ord-3dd530392f6c4f4c94c6f62c18bf6585
出典データセット
uspto-grants-2001_12
特許番号
US06329381B1

反応ノート

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