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1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- → 6-Amino-9-benzyl-8-hydroxy-2-(3-phthalimidopropylthio)purine

HRID 2269028
ノート
印刷プレビュー

反応式

HRID 2269028 の反応式
[NH2:1][C:2]1[N:10]=[C:9]([SH:11])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:19])[N:6]2[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[C:20](=O)([O-])[O-].[K+].[K+].[C:26]1(=[O:39])[N:30]([CH2:31][CH2:32]Br)[C:29](=[O:34])[C:28]2=[CH:35][CH:36]=[CH:37][CH:38]=[C:27]12>CN(C)C=O>[NH2:1][C:2]1[N:10]=[C:9]([S:11][CH2:20][CH2:32][CH2:31][N:30]2[C:29](=[O:34])[C:28]3=[CH:35][CH:36]=[CH:37][CH:38]=[C:27]3[C:26]2=[O:39])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:19])[N:6]2[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-HCID 11430Potassium CarbonateHCID 1785090596-Amino-9-benzyl-8-hydroxy-2-mercaptopurine

生成物 1

HCID 1785090456-Amino-9-benzyl-8-hydroxy-2-(3-phthalimidopropylthio)purine収率 75%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

6-Amino-9-benzyl-8-hydroxy-2-mercaptopurine (110 mg, 0.40 mmol) was suspended in dimethylformamide (10 ml). To the suspension were added potassium carbonate (50 mg, 0.40 mmol) and 2-phthalimidoethyl bromide (108 mg, 0.40 mmol) in order. The mixture was stirred at room temperature for 2 hours. The solvent was removed in vacuo, water and methanol were added to the residue, and the resulting crystals were taken by filtration to give the subject compound (138 mg, yield 75%).

後処理

  1. customThe solvent was removed in vacuo, water and methanol
  2. additionwere added to the residue
  3. filtrationthe resulting crystals were taken by filtration

出典と根拠

ORDレコード
ord-5f1899c1cbe748bbb5bed8fd6977008e
出典データセット
uspto-grants-2001_12
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06329381B1

反応ノート

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