Potassium Carbonate → HCID 178509043、化合物

HRID 2269029

反応式

HRID 2269029 の反応式
[NH2:1][C:2]1[N:10]=[C:9]([SH:11])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:19])[N:6]2[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+].[C:26]1(=[O:41])[N:30]([CH2:31][CH2:32][CH2:33][CH2:34]Br)[C:29](=[O:36])[C:28]2=[CH:37][CH:38]=[CH:39][CH:40]=[C:27]12>CN(C)C=O>[NH2:1][C:2]1[N:10]=[C:9]([S:11][CH2:34][CH2:33][CH2:32][CH2:31][N:30]2[C:26](=[O:41])[C:27]3=[CH:40][CH:39]=[CH:38][CH:37]=[C:28]3[C:29]2=[O:36])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:19])[N:6]2[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 93575N-(4-Bromobutyl)phthalimideHCID 1785090596-Amino-9-benzyl-8-hydroxy-2-mercaptopurine

生成物 1

HCID 178509043HCID 178509043、化合物収率 74.3%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

6-Amino-9-benzyl-8-hydroxy-2-mercaptopurine (120 mg, 0.44 mmol) was suspended in dimethylformamide (10 ml). To the suspension were added potassium carbonate (60 mg, 0.43 mmol) and 4-phthalimidobutyl bromide (113 mg, 0.40 mmol) in order. The mixture was stirred at room temperature for 2 hours. The solvent was removed in vacuo, and water and methanol were added to the residue, and the resulting crystals were taken by filtration to give the subject compound (141 mg, yield 74%).

後処理

  1. customThe solvent was removed in vacuo, and water and methanol
  2. additionwere added to the residue
  3. filtrationthe resulting crystals were taken by filtration

出典と根拠

ORDレコード
ord-bb7ba8c4f634447aac52370405f128e4
出典データセット
uspto-grants-2001_12
特許番号
US06329381B1

関連ノート

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