6-Amino-9-benzyl-2-(2-ethoxyethoxy)-8-methoxypurine → HCID 178467997、化合物
反応式
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][O:14][CH2:15][CH3:16])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:24]C)[N:6]2[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>Cl>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][O:14][CH2:15][CH3:16])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:24])[N:6]2[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1参加物
3
実験手順
6-Amino-9-benzyl-2-(2-ethoxyethoxy)-8-methoxypurine (110 mg, 0.32 mmol) in concentrated hydrochloric acid (20 ml) was stirred at room temperature for 12 hours. The reaction mixture was evaporated in vacuo to dryness and then 28% aqueous ammonia was added thereto. The resulting crystals were filtered to give the subject compound (88 mg, yield 84%).
後処理
- customThe reaction mixture was evaporated in vacuo to dryness
- addition28% aqueous ammonia was added
- filtrationThe resulting crystals were filtered