4-(Trifluoromethyl)aniline → HCID 178500756、化合物

関与物質

反応手順

Compound 2c was prepared following the procedure described in Step 2 of Example 1 using 598 mg (2.41 mmol) of the crude 2-(3,4-dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester 1a and 427 mg (2.65 mmol) of 4-trifluoromethyl-phenylamine. The product 2c was purified by flash chromatography (0-40% ethyl acetate in hexane) to yield 151 mg of 2-(3,4-dimethyl-benzoyl)-3-(4-trifluoromethyl-phenylamino)-acrylic acid methyl ester as a yellow crystalline solid: LC-MSD, m/z for C20H18F3NO3 [M+H]+=378.5; HPLC retention time: 3.0 min.

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