Hydrochloric Acid → HCID 70212260、化合物

HRID 2269345ノート

反応式

HRID 2269345 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][C:8](=[O:22])[C@@H:9]([NH:14]C(OC(C)(C)C)=O)[C:10]([CH3:13])([CH3:12])[CH3:11])[CH:2]=1.[ClH:23]>ClCCl.O1CCOCC1>[ClH:23].[ClH:23].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][C:8](=[O:22])[C@@H:9]([NH2:14])[C:10]([CH3:11])([CH3:12])[CH3:13])[CH:2]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 70212244HCID 70212244、化合物

生成物 1

HCID 70212260HCID 70212260、化合物収率 94%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

反応条件

温度
25 °C

実験手順

To a solution of (2S)-2-tert-butoxycarbonylamino-3,3-dimethylbutanoic acid 3-pyridylamide (1.6 g, 5.21 mmol) in dichloromethane (10 mL) cooled at 0° C. is added 4 M HCl in dioxane (10 mL). The resulting solution is allowed to warm to 25° C. and is stirred for 3 h. The reaction mixture is concentrated and the solid is filtered to provide (2S)-2-amino-3,3-dimethylbutanoic acid 3-pyridylamide dihydrochloride (1.40 g, 94% yield) as a white solid.

後処理

  1. concentrationThe reaction mixture is concentrated
  2. filtrationthe solid is filtered

出典と根拠

ORDレコード
ord-a10bcdccca694dd88a9f6a3686a9bccc
出典データセット
uspto-grants-2001_12
特許番号
US06329400B1

反応ノート

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