2-[2-(4-Fluorophenyl)acetyl]4-methoxy-pyrazolidine-1-carboxylic acid benzyl ester → 2-(4-Fluorophenyl)-1-(4-methoxy-pyrazolidin-1-yl)-ethanone

HRID 22694

反応式

HRID 22694 の反応式
C(OC([N:11]1[CH2:15][CH:14]([O:16][CH3:17])[CH2:13][N:12]1[C:18](=[O:27])[CH2:19][C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=1)=O)C1C=CC=CC=1>CO>[F:26][C:23]1[CH:24]=[CH:25][C:20]([CH2:19][C:18]([N:12]2[CH2:13][CH:14]([O:16][CH3:17])[CH2:15][NH:11]2)=[O:27])=[CH:21][CH:22]=1

参加物

3

反応物 1

HCID 207247452-[2-(4-Fluorophenyl)acetyl]4-methoxy-pyrazolidine-1-carboxylic acid benzyl ester

生成物 1

HCID 219921912-(4-Fluorophenyl)-1-(4-methoxy-pyrazolidin-1-yl)-ethanone

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-[2-(4-Fluorophenyl)acetyl]-4-methoxy-pyrazolidine-1-carboxylic acid benzyl ester, 46, (12.0 g, 32.2 mmol) is dissolved in methyl alcohol (300 mL). The flask is flushed with nitrogen and charged with 10% palladium on carbon (1.2 g). The reaction mixture is stirred vigorously at room temperature under 1 atmosphere of hydrogen gas for 3 hours. The flask is flushed with nitrogen and the reaction mixture filtered through a pad of Celite, rinsing with ethyl acetate (100 mL). The filtrate is concentrated in vacuo to afford 7.67 g of the desired product as a viscous, clear oil.

後処理

  1. customThe flask is flushed with nitrogen
  2. additioncharged with 10% palladium on carbon (1.2 g)
  3. customThe flask is flushed with nitrogen
  4. filtrationthe reaction mixture filtered through a pad of Celite
  5. washrinsing with ethyl acetate (100 mL)
  6. concentrationThe filtrate is concentrated in vacuo

出典と根拠

ORDレコード
ord-f6d9ae5a61c6420e86026a76fb33c4ce
出典データセット
uspto-grants-2005_02
特許番号
US06849627B2

関連ノート

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