HCID 178500760、化合物 → 3-(3,4-dimethylbenzoyl)-6-fluoroquinolin-4(1H)-one

HRID 226962

反応式

HRID 226962 の反応式
CO[C:3](=[O:24])[C:4]([C:14](=[O:23])[C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[C:17]([CH3:22])[CH:16]=1)=[CH:5][NH:6][C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1>C1(OC2C=CC=CC=2)C=CC=CC=1.CCCCCC>[CH3:22][C:17]1[CH:16]=[C:15]([CH:20]=[CH:19][C:18]=1[CH3:21])[C:14]([C:4]1[C:3](=[O:24])[C:8]2[C:7](=[CH:12][CH:11]=[C:10]([F:13])[CH:9]=2)[NH:6][CH:5]=1)=[O:23]

参加物

4

反応物 1

HCID 178500760HCID 178500760、化合物

生成物 1

HCID 46065703-(3,4-dimethylbenzoyl)-6-fluoroquinolin-4(1H)-one収率 66.1%

試薬・触媒・溶媒 2

HCID 7583Diphenyl Ether溶媒HCID 8058Hexane溶媒

実験手順

0.691 g (2.11 mmol) of 2-(3,4-Dimethyl-benzoyl)-3-(4-fluoro-phenylamino)-acrylic acid methyl ester 2g was dissolved in 30 mL of diphenyl ether and the resultant solution was heated at 250° C. After 2.5 h the solution was cooled to room temperature and diluted with 50 mL of hexane. The crude product precipitated out of solution and was isolated by filtration. The crude product was further washed with hexane to yield 0.412 g of 3-(3,4-dimethyl-benzoyl)-6-fluoro-1H-quinolin-4-one 3j as a brown solid.

後処理

  1. customThe crude product precipitated out of solution
  2. customwas isolated by filtration
  3. washThe crude product was further washed with hexane

出典と根拠

ORDレコード
ord-07f7734ea7a1418e94850b8843af144c
出典データセット
uspto-grants-2009_07
特許番号
US07557213B2

関連ノート

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