Dimethylformamide → 2-Benzofurancarbonitrile
反応式
C(=O)([O-])[O-].[K+].[K+].CN(C=O)C.[CH:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[O:20][CH2:21][C:22]#[N:23])=O>O>[O:20]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[CH:12]=[C:21]1[C:22]#[N:23]参加物
5
反応条件
- 温度
- 60 °C
実験手順
Potassium carbonate (65.2 g) was added to a DMF solution (500 ml) of (2-formylphenyl)oxyacetonitrile (38 g), which was stirred at 60° C. for 2.5 hours. Water was added to the reaction mixture, which was extracted with diethyl ether. The organic layer was washed with water and a saturated aqueous sodium chloride solution, then dried and concentrated. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=10/1) to obtain the entitled compound (14.5 g).
後処理
- extractionwas extracted with diethyl ether
- washThe organic layer was washed with water
- dry with materiala saturated aqueous sodium chloride solution, then dried
- concentrationconcentrated
- customThe residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=10/1)
出典と根拠
- ORDレコード
- ord-e53149382d97478f886055c80c2dc03a
- 出典データセット
- uspto-grants-2001_12
- 特許番号
- US06329389B1
反応ノート
読み込み中…