Ethanol → Ethyl 3-[4-(2-benzofuranyl)thiazol-2-yl]propionate

HRID 2269707ノート

反応式

HRID 2269707 の反応式
Br[CH2:2][C:3]([C:5]1[O:6][C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[CH:9]=1)=O.[CH2:14](O)C.[NH2:17][C:18](=[S:25])[CH2:19][CH2:20][C:21]([O:23][CH3:24])=[O:22]>O>[O:6]1[C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[CH:9]=[C:5]1[C:3]1[N:17]=[C:18]([CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:14])=[O:22])[S:25][CH:2]=1

参加物

5

反応物 3

HCID 702EthanolHCID 27354511-(1-Benzofuran-2-Yl)-2-Bromoethan-1-OneHCID 18333020Methyl 4-amino-4-thioxobutanoate

生成物 1

HCID 18333015Ethyl 3-[4-(2-benzofuranyl)thiazol-2-yl]propionate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2-(Bromoacetyl)benzofuran (650 ml) was added to an ethanol (12 ml) solution of methyl 4-amino-4-thioxobutyrate (400 mg), which was heated under reflux overnight. After cooling, water was added to the reaction mixture, which was extracted with ethyl acetate. The organic layer was dried, concentrated, and then purified by silica gel column chromatography (eluent: hexane/ethyl acetate=4/1). The obtained crystals were washed with hexane to obtain ethyl 3-[4-(2-benzofuranyl)thiazol-2-yl]propionate (460 mg).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux overnight
  3. temperatureAfter cooling
  4. extractionwas extracted with ethyl acetate
  5. customThe organic layer was dried
  6. concentrationconcentrated
  7. custompurified by silica gel column chromatography (eluent: hexane/ethyl acetate=4/1)
  8. washThe obtained crystals were washed with hexane

出典と根拠

ORDレコード
ord-81ba8f4e2d634cbfbf9dcde51199b65d
出典データセット
uspto-grants-2001_12
特許番号
US06329389B1

反応ノート

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