関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diphenyl Ether | HCID 7583 | — |
| 反応物 | 2,6-Dimethyl-3-pyridylamine | HCID 76964 | — |
| 反応物 | 2-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester | HCID 66879272 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | 3-(3,4-Dimethyl-benzoyl)-6,8-dimethyl-1H-[1,7]naphthyridin-4-one | HCID 57754774 | 7.3% |
反応手順
0.50 g (2.01 mmol) of 2-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester and 0.25 g (2.01 mmol) of 2,6-Dimethyl-pyridin-3-ylamine were heated at 100° C. for two hours. After cooling to room temperature 30 mL of diphenyl ether was added and heated at 250° C. for two hours. The reaction was allowed to cool to room temperature and hexane was added. The brown precipitate was collected by filtration to yield 45 mg of 3-(3,4-Dimethyl-benzoyl)-6,8-dimethyl-1H-[1,7]naphthyridin-4-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07557213B2 |
|---|
| 出典データセット | uspto-grants-2009_07 |
|---|
| ORD ID | ord-dc698529e612467bb9d0b10d8a737455 |
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| 出典メモ | uspto-grants-2009_07 |
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