3-(2-Amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid ethyl ester → 6,7-Dimethoxy-3-methyl-carbostyril

HRID 2269781ノート

反応式

HRID 2269781 の反応式
C([O:3][C:4](=O)[C:5]([CH3:18])=[CH:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[C:10]([O:15][CH3:16])=[CH:9][C:8]=1[NH2:17])C>C(O)C>[CH3:14][O:13][C:11]1[CH:12]=[C:7]2[C:8](=[CH:9][C:10]=1[O:15][CH3:16])[NH:17][C:4](=[O:3])[C:5]([CH3:18])=[CH:6]2

参加物

3

反応物 1

HCID 702131123-(2-Amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid ethyl ester

生成物 1

HCID 183480236,7-Dimethoxy-3-methyl-carbostyril収率 92%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Into 30 ml of ethyl alcohol, 0.5 g of 3-(2-amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid ethyl ester was dissolved. This solution was irradiated with ultraviolet rays at 365 nm for about 20 hours, and the precipitated crystal was filtered out. This crystal was recrystallized from ethanol, whereby 0.38 g of the aimed compound was obtained (yield: 92%).

後処理

  1. customThis solution was irradiated with ultraviolet rays at 365 nm for about 20 hours
  2. filtrationthe precipitated crystal was filtered out
  3. customThis crystal was recrystallized from ethanol

出典と根拠

ORDレコード
ord-d163b67745eb45f392d832254474f72a
出典データセット
uspto-grants-2001_12
特許番号
US06329546B1

反応ノート

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