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3-Amino-4-picoline → 3-(3,4-Dimethyl-benzoyl)-8-methyl-1H-[1,5]naphthyridin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Amino-4-picoline | HCID 137935 | — |
| 反応物 | 2-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester | HCID 66879272 | — |
| 溶媒 | Diphenyl Ether | HCID 7583 | — |
| 生成物 | 3-(3,4-Dimethyl-benzoyl)-8-methyl-1H-[1,5]naphthyridin-4-one | HCID 57754561 | 16.1% |
反応手順
Experimental conditions analogous to those described for Step 1 of Example 1 were used with 0.50 g (2.01 mmol) 2-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester, 0.22 g (2.01 mmol) of 4-Methyl-pyridin-3-ylamine, and 30 mL of diphenyl ether to yield 94.4 mg of 3-(3,4-Dimethyl-benzoyl)-8-methyl-1H-[1,5]naphthyridin-4-one as a brown solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07557213B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-737a50d3f24547abb218a569d40486d7 |
| 出典メモ | uspto-grants-2009_07 |