化工社化工社 化学情報印刷レポート · 研究参考用
Diethyl (ethoxymethylene)malonate → Diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| 反応物 | 2-Amino-6-methylpyridine | HCID 15765 | — |
| 生成物 | Diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonate | HCID 83264 | 84.7% |
反応手順
20 g (92.5 mmol) of 2-ethoxymethylene-malonic acid diethyl ester and 10 g (92.5 mmol) of 2-amino-6-methylpyridine were heated neat at 110° C. for 2 h. The reaction was allowed to cool to room temperature and the product was recrystallized from dichloromethane and hexane to afford 21.8 g of 2-[(6-Methyl-pyridin-2-ylamino)-methylene]-malonic acid diethyl ester as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07557213B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-6679bb50a1b64b42a9bc552543a97405 |
| 出典メモ | uspto-grants-2009_07 |