関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hexane | HCID 8058 | — |
| 反応物 | Diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonate | HCID 83264 | — |
| 溶媒 | Diphenyl Ether | HCID 7583 | — |
| 生成物 | HCID 86613649 | HCID 86613649 | — |
反応手順
21.8 g (3.61 mmol) of 2-[(6-Methyl-pyridin-2-ylamino)-methylene]-malonic acid diethyl ester was dissolved in 300 mL of diphenyl ether and the solution was heated at 250° C. After 2.5 h the solution was cooled to rt and 50 mL of hexane was added. The mixture was filtered and the solid washed with hexane to yield 18.5 g of -Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester as a brown solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07557213B2 |
|---|
| 出典データセット | uspto-grants-2009_07 |
|---|
| ORD ID | ord-d1b60e42c46b4bb7ade946be2e5a443f |
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| 出典メモ | uspto-grants-2009_07 |
|---|
