Hydrochloric Acid → 4-(1-(2-allyloxyethyl)-1H-benzimidazole-2-carbonyl)piperidine

HRID 2269875ノート

反応式

HRID 2269875 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([C:16]2[N:20]([CH2:21][CH2:22][O:23][CH2:24][CH:25]=[CH2:26])[C:19]3[CH:27]=[CH:28][CH:29]=[CH:30][C:18]=3[N:17]=2)=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[CH2:24]([O:23][CH2:22][CH2:21][N:20]1[C:19]2[CH:27]=[CH:28][CH:29]=[CH:30][C:18]=2[N:17]=[C:16]1[C:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[O:15])[CH:25]=[CH2:26]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 183332581-(t-butoxycarbonyl)-4-(1-(2-allyloxyethyl)-1H-benzimidazole-2-carbonyl)piperidine

生成物 1

HCID 183334304-(1-(2-allyloxyethyl)-1H-benzimidazole-2-carbonyl)piperidine

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

Combine 1-(t-butoxycarbonyl)-4-(1-(2-allyloxy-ethyl)-1H-benzoimidazole-2-carbonyl)-piperidine (1.0 mmol) and dioxane (3 mL). Add a solution of hydrochloric acid in dioxane (4 mL, 4 M, 16 mmol). After 30 minutes, partition the residue between ethyl acetate and saturated aqueous sodium bicarbonate solution. Separate the organic layer and extract with saturated aqueous sodium chloride solution. Dry the organic layer over Na2SO4, filter, and evaporate in vacuo to give the title compound.

後処理

  1. custompartition the residue between ethyl acetate and saturated aqueous sodium bicarbonate solution
  2. customSeparate the organic layer
  3. extractionextract with saturated aqueous sodium chloride solution
  4. dry with materialDry the organic layer over Na2SO4
  5. filtrationfilter
  6. customevaporate in vacuo

出典と根拠

ORDレコード
ord-3e50169f59434ef9a8528ece97a533ac
出典データセット
uspto-grants-2001_12
特許番号
US06329392B1

反応ノート

読み込み中…