Boron tribromide → Benzoxazole

HRID 22700

反応式

HRID 22700 の反応式
CO[C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9](C3C=CC=C(C(F)(F)F)C=3)=[N:8][C:7]=2[CH:21]=1.B(Br)(Br)Br>C(Cl)Cl>[O:10]1[C:6]2[CH:5]=[CH:4][CH:3]=[CH:21][C:7]=2[N:8]=[CH:9]1

参加物

4

反応物 2

HCID 25134Boron tribromideHCID 121354125-Methoxy-2-(3-trifluoromethylphenyl)-benzoxazole

生成物 1

HCID 9228Benzoxazole

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of compound 10 (200 mg, 0.68 mmol) in CH2Cl2 (5 mL) was added BBr3 (1M in CH2Cl2, 1 mL, 1 mmol) dropwise. The resulting solution was allowed to stir for 48 h. The solvent was removed by evaporation (in vacuo) and the residue was dissolved in ethyl acetate and washed with saturated NaHCO3. The organic layer was dried over MgSO4 and evaporated (in vacuo). The residue was purified using column chromatography (30% ethyl acetate/hexanes) to yield compound 8 as a white solid.

後処理

  1. customThe solvent was removed by evaporation (in vacuo)
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washwashed with saturated NaHCO3
  4. dry with materialThe organic layer was dried over MgSO4
  5. customevaporated (in vacuo)
  6. customThe residue was purified

出典と根拠

ORDレコード
ord-8ac68bc3d6084837bdd5e28d1f8cad1a
出典データセット
uspto-grants-2005_02
特許番号
US06849632B2

関連ノート

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