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5-Amino-2-methylpyridine → 3-(4-Methoxy-3-methyl-benzoyl)-6-methyl-1H-[1,5]naphthyridin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Amino-2-methylpyridine | HCID 243313 | — |
| 反応物 | 3-Ethoxy-2-(4-methoxy-3-methyl-benzoyl)-acrylic acid methyl ester | HCID 66878626 | — |
| 溶媒 | Diphenyl Ether | HCID 7583 | — |
| 生成物 | 3-(4-Methoxy-3-methyl-benzoyl)-6-methyl-1H-[1,5]naphthyridin-4-one | HCID 57754706 | 56.9% |
反応手順
Experimental conditions analogous to those described for Step 1 of Example 1 were used with 0.50 g (1.88 mmol) of 3-ethoxy-2-(4-methoxy-3-methyl-benzoyl)-acrylic acid methyl ester, 0.20 g (1.88 mmol) of 6-Methyl-pyridin-3-ylamine, and 10 mL of diphenyl ether to yield 0.33 g of 3-(4-Methoxy-3-methyl-benzoyl)-6-methyl-1H-[1,5]naphthyridin-4-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07557213B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-2b9834e73ab544c49c9d92747a0ce5c9 |
| 出典メモ | uspto-grants-2009_07 |