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Diphenyl Ether → 3-(3-Fluoro-4-methoxy-benzoyl)-6-methyl-1H-[1,5]naphthyridin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diphenyl Ether | HCID 7583 | — |
| 反応物 | 5-Amino-2-methylpyridine | HCID 243313 | — |
| 反応物 | 3-Ethoxy-2-(3-fluoro-4-methoxy-benzoyl)acrylic acid methyl ester | HCID 66879749 | — |
| 生成物 | 3-(3-Fluoro-4-methoxy-benzoyl)-6-methyl-1H-[1,5]naphthyridin-4-one | HCID 57754627 | 40.1% |
反応手順
Experimental conditions analogous to those described for Step 1 of Example 1 were used with 0.50 g (1.86 mmol) of 3-Ethoxy-2-(3-fluoro-4-methoxy-benzoyl) acrylic acid methyl ester, 0.20 g (1.86 mmol) of 6-Methyl-pyridin-3-ylamine, and 15 mL of diphenyl ether to yield 0.233 g of 3-(3-Fluoro-4-methoxy-benzoyl)-6-methyl-1H-[1,5]naphthyridin-4-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07557213B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-7f3268ff5099482da893501dce9868c8 |
| 出典メモ | uspto-grants-2009_07 |