Diisopropylamine → HCID 22632867、化合物

反応式

[Li]CCCC.C(NC(C)C)(C)C.[F:13][C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=1.F[C:22]1[CH:30]=[C:29]([F:31])[C:28]([F:32])=[CH:27][C:23]=1[C:24]([OH:26])=[O:25]>>[F:13][C:14]1[CH:20]=[CH:19][C:17]([NH:18][C:22]2[CH:30]=[C:29]([F:31])[C:28]([F:32])=[CH:27][C:23]=2[C:24]([OH:26])=[O:25])=[CH:16][CH:15]=1

参加物

反応物 4

HCID 7912Diisopropylamine

HCID 97314-Fluoroaniline

HCID 5211702,4,5-Trifluorobenzoic acid

HCID 178418339Butyllithium

生成物 1

HCID 22632867HCID 22632867、化合物収率 88.1%

実験手順

Using General Method 1, the reaction of 2.5 M solution of n-BuLi in hexanes (14 mL, 35 mmol), diisopropylamine (4.8 mL, 34 mmol), 4-fluoro-aniline (1.1 mL, 11 mmol), and 2,4,5-trifluorobenzoic acid (2 g, 11 mmol) provided 2.59 g of the crude title compound.

出典と根拠

ORDレコード: ord-6ae762341855465a8193996dae6b7059
出典データセット: uspto-grants-2001_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06331538B1

反応ノート

読み込み中…