Acetone → Ethyl 2-[(4-ethoxyphenyl)sulfanyl]propanoate

HRID 2270320ノート

反応式

HRID 2270320 の反応式
[CH2:1]([O:3][C:4](=[O:15])[CH:5]([S:7][C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=1)[CH3:6])[CH3:2].C([O-])([O-])=O.[K+].[K+].[CH3:22][C:23](C)=O>>[CH2:1]([O:3][C:4](=[O:15])[CH:5]([S:7][C:8]1[CH:9]=[CH:10][C:11]([O:14][CH2:22][CH3:23])=[CH:12][CH:13]=1)[CH3:6])[CH3:2]

参加物

4

反応物 3

HCID 180AcetoneHCID 11430Potassium CarbonateHCID 109771882-[(4-Hydroxyphenyl)thio]propanoic acid ehtyl ester

生成物 1

HCID 10934051Ethyl 2-[(4-ethoxyphenyl)sulfanyl]propanoate

実験手順

To stirred solution of 2-(4-hydroxy-phenylsulfanyl)-propionic acid ethyl ester (11.3 g, 50 mmol), and K2CO3 (50 g, excess) in acetone (300 ml) ethyl iodide (20 ml, excess) was added and refluxed for 8 hrs. At the end, reaction mixture was filtered and concentrated. The residue obtained was extracted with chloroform and washed well with water. It was dried and concentrated. The product, 2-(4ethoxy-phenylsulfanyl)-propionic acid ethyl ester was isolated as colorless oil. Yield: 12.0 g, 98%; MS: 255 (M+H).

後処理

  1. additionwas added
  2. temperaturerefluxed for 8 hrs
  3. customAt the end, reaction mixture
  4. filtrationwas filtered
  5. concentrationconcentrated
  6. customThe residue obtained
  7. extractionwas extracted with chloroform
  8. washwashed well with water
  9. customIt was dried
  10. concentrationconcentrated

出典と根拠

ORDレコード
ord-d436633a50ea40ab97898004ad653f5b
出典データセット
uspto-grants-2001_12
特許番号
US06331563B1

反応ノート

読み込み中…