関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4,5-Dimethylthiazole | HCID 62510 | — |
| 反応物 | Magnesium Bromide | HCID 82241 | — |
| 反応物 | 1-(6-Bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide | HCID 57754532 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Thiazole | HCID 9256 | — |
| 生成物 | HCID 57754582 | HCID 57754582 | — |
反応手順
585 mg (5.17 mmol) of 4,5-dimethylthiazole was dissolved in 10 mL of anhydrous THF and cooled down to −78° C. 2.07 mL of 2.5 M BuLi in hexanes was added dropwise, followed after 15 minutes by 1.0 g of anhydrous magnesium bromide. The solution was warmed up to rt. The final compound was prepared from 120 mg (0.30 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 2 mL THF and 1.64 mL of the thiazole salt solution. Yield: 13 mg of a white solid. LC-MSD, m/z for C21H16BrN3O2S [M+H]+=454.0, 456.0; HPLC retention time: 2.2 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07557213B2 |
|---|
| 出典データセット | uspto-grants-2009_07 |
|---|
| ORD ID | ord-059639348c8b42119398978851e28049 |
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| 出典メモ | uspto-grants-2009_07 |
|---|
