3-Iodo-2,6-dimethylpyridine → 1-(6-Bromo-pyridin-2-ylmethyl)-3-(2,6-dimethyl-pyridine-3-carbonyl)-1H-quinolin-4-one

関与物質

反応手順

Experimental conditions analogous to those described for Step 6 of Example 60 from 105 mg (0.26 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 1 mL THF and 134 mg (0.58 mmol) of 2,6-dimethyl-5-iodo-pyridine in 1 mL THF with 0.30 mL 2M isopropylmagnesium chloride. Yield: 19 mg of a white powder. LC-MSD, m/z for C23H18BrN3O2 [M+H]+=448.0, 450.0; HPLC retention time: 1.2 min.

情報源と証拠