化工社化工社 化学情報印刷レポート · 研究参考用
Sodium hydride → 1-(6-Methyl-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate | HCID 220876 | — |
| 反応物 | 2-(Bromomethyl)-6-methylpyridine | HCID 12543733 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(6-Methyl-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester | HCID 57754776 | 74.7% |
反応手順
Experimental conditions analogous to those described for Step 3 of Example 1, from 2.87 g (13.2 mmol) of 4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester, 0.64 g (15.9 mmol) of 60% sodium hydride, 2.95 g (15.9 mmol) of 2-bromomethyl-6-methyl-pyridine in 30 mL DMF to give 3.18 g of the product as an off-white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07557213B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-38a2610cbcca49fd9db4fbbca641b4d2 |
| 出典メモ | uspto-grants-2009_07 |