(5-Methylthiophen-2-yl)boronic acid → N-[5-(5-methyl-2-thienyl)thiophene-2-sulfonyl]pyrrole

HRID 2270731ノート

反応式

HRID 2270731 の反応式
[CH3:1][C:2]1[S:3][C:4](B(O)O)=[CH:5][CH:6]=1.Br[C:11]1[S:15][C:14]([S:16]([N:19]2[CH:23]=[CH:22][CH:21]=[CH:20]2)(=[O:18])=[O:17])=[CH:13][CH:12]=1>>[CH3:1][C:2]1[S:3][C:4]([C:11]2[S:15][C:14]([S:16]([N:19]3[CH:23]=[CH:22][CH:21]=[CH:20]3)(=[O:17])=[O:18])=[CH:13][CH:12]=2)=[CH:5][CH:6]=1

参加物

3

反応物 2

HCID 2734374(5-Methylthiophen-2-yl)boronic acidHCID 23445587N-(5-bromothiophenesulfonyl)pyrrole

生成物 1

HCID 22998476N-[5-(5-methyl-2-thienyl)thiophene-2-sulfonyl]pyrrole収率 72%

実験手順

N-[5-(5-methyl-2-thienyl)thiophene-2-sulfonyl]pyrrole was prepared in the same manner as described in Example 32C from 2-methylthiophene-5-boronic acid and N-(5-bromothiophene-2-sulfonyl) pyrrole. Purification by column chromatography using 2% ether/hexanes gave the pure sulfonamide in 72% yield as a white solid.

後処理

  1. customPurification by column chromatography

出典と根拠

ORDレコード
ord-b28905de5e0746b3928326fe6ffcf578
出典データセット
uspto-grants-2001_12
特許番号
US06331637B1

反応ノート

読み込み中…