Sodium Methoxide → 1-(3-Chloro-benzyl)-3-(6-methoxy-pyridine-3-carbonyl)-1H-quinolin-4-one

HRID 227086ノート

反応式

HRID 227086 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][CH:28]=1)[CH2:5][N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9](=[O:16])[C:8]([C:17]([C:19]2[CH:20]=[N:21][C:22](Cl)=[CH:23][CH:24]=2)=[O:18])=[CH:7]1.[CH3:29][O-:30].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][CH:28]=1)[CH2:5][N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9](=[O:16])[C:8]([C:17]([C:19]2[CH:20]=[N:21][C:22]([O:30][CH3:29])=[CH:23][CH:24]=2)=[O:18])=[CH:7]1

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 577546041-(3-Chloro-benzyl)-3-(6-chloro-pyridine-3-carbonyl)-1H-quinolin-4-one

生成物 1

HCID 577546421-(3-Chloro-benzyl)-3-(6-methoxy-pyridine-3-carbonyl)-1H-quinolin-4-one収率 89.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Experimental conditions analogous to those described for Step 6 of Example 60, from 151 mg (0.37 mmol) of 1-(3-chloro-benzyl)-3-(6-chloro-pyridine-3-carbonyl)-1H-quinolin-4-one and 170 mg (3.15 mmol) of sodium methoxide were stirred in 2 mL of dry methanol in a sealed vessel at 75° C. for 2 h. The reaction mixture was evaporated and purified by flash chromatography to give 134 mg of a white powder. LC-MSD, m/z for C23H17ClN2O3 [M+H]+=405.1, 407.1; HPLC retention time: 2.3 min.

後処理

  1. customThe reaction mixture was evaporated
  2. custompurified by flash chromatography

出典と根拠

ORDレコード
ord-b3dd80b3e27b48c489ebeebe36ec1ce6
出典データセット
uspto-grants-2009_07
特許番号
US07557213B2

反応ノート

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