Phenylmethyl 4-{[N-(2,6-dimethylphenyl)carbamoyl]methyl}-3-oxopiperazinecarboxylate → N-(2,6-dimethylphenyl)-2-(2-oxopiperazinyl)-acetamide
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10]([CH2:12][N:13]1[CH2:18][CH2:17][N:16](C(OCC2C=CC=CC=2)=O)[CH2:15][C:14]1=[O:29])=[O:11].[H][H]>CO>[CH3:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[C:3]=1[NH:9][C:10](=[O:11])[CH2:12][N:13]1[CH2:18][CH2:17][NH:16][CH2:15][C:14]1=[O:29]参加物
4
実験手順
To a solution of compound 31 in methanol (10 mL) 10% palladium on carbon was added. The reaction vessel was charged with hydrogen (40 p.s.i) and agitated for 4 h. The catalyst was removed by filtration and the filtrate was concentrated and purified using column chromatography (1:15 MeOH:DCM) to yield compound 32 as a semi solid.
後処理
- customThe catalyst was removed by filtration
- concentrationthe filtrate was concentrated
- custompurified
出典と根拠
- ORDレコード
- ord-4ce1d534c97d41de9f8f32b8504fdead
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06849632B2
反応ノート
読み込み中…